onepagecdn
Rated
(5)
NMN15000
$235.00$269.99
Last Minute - Sale ends in  13:08 
Purchase options

Limited stock! people are viewing this and purchased it.
Description

Image

What Is In NMN15000?

INGREDIENTS: NMN. That's it. 100% Pure. 100% Natural.

NMN15000 is made from 100% pure NMN (Nicotinamide Mononucleotide), a natural compound found in every cell of the body that boosts NAD+ levels for cellular energy and repair. Unlike most NMN products that may contain impurities or fillers, our NMN is pharmaceutical-grade, produced to the highest standards for purity. It is derived naturally and processed without synthetic additives, ensuring that you’re getting the cleanest, most effective form of NMN available.

Image

Image

Image

Image

Image

 

Image

How do NMN supplements work?

Nicotinamide mononucleotide (NMN) is a derivative of niacin (vitamin B3). Research has shown that NMN is rapidly absorbed and converted to nicotinamide adenine dinucleotide (NAD+) through a series of chemical transformations. NMN supplements work by replenishing diminished NAD+ levels, which naturally fall at a rate of approximately 1% a year. NMN supplementation has been shown to increase NAD+ levels in our body, which may help to slow down the aging process.

Learn more about the science behind NMN – a stable, reliable NAD+activator and anti-aging molecule. [Lern more]

 

Image

A power source for cells

NAD+ is a critical coenzyme present in every living cell, involved in myriad metabolic processes to maintain cellular youth.

NAD+ levels in our organs and tissues including the pancreas, fat, skeletal muscles, liver, and brain fall as we grow older

As we age, NAD+ levels in organs and tissues such as the pancreas, fat, skeletal muscles, liver, and brain decline.

What is the relationship between NMN and NAD+?

NMN serves as a potent precursor for NAD+, a critical coenzyme in the human body. NAD+ regulates DNA damage repair, immune response, gene expression, and metabolism, with widely recognized anti-aging effects.

Image

Why Our NMN Stands Out

Image

Pharmaceutical-Grade Purity

Each bottle contains 15,000 mg of the highest quality NMN. Starting NMN used in manufacturing of our product is 99.9% purity.

Image

Extended 12-Hour Release

Each tablet is made with advanced delivery technology to ensure continuous and even delivery of NMN, maximizing absorption.

Image

Clean and Safe

Made in an FDA-inspected pharmaceutical-grade facility. Free from allergens and additives.

Image

Rigorous Testing

Undergoes strict quality checks and three-level testing, including globally recognized, independent labs.

Benefits of NMN Supplements

Support DNA protection and repair  
Enhance energy production and alleviate fatigue 
Reduce susceptibility to age-related diseases 
Enhance cognitive function and memory 
Help increase muscle strength and endurance 
Improve skin health and mitigate aging indicators

Telomeres, molecular structures capping chromosome ends, act as a molecular clock. With each cell division, telomeres shorten. Upon reaching a critical length, cells cease division, becoming senescent or dysfunctional, leading to aging.

NAD+ can mitigate telomere dysfunction by restoring levels of Sirtuin (a key longevity factor) and PARP (a DNA repair enzyme).

Sirtuin and PARP play critical roles in cellular aging pathways, with studies showing their epigenomic regulation significantly affects aging.

NMN also addresses senescent cells (i.e. “zombie cells”). When a cell becomes mutated or injured, it often stops dividing and becomes senescent. Senescent cells excrete a glut of molecules — including cytokines, growth factors, and proteases — that affect the function of nearby cells and incite local inflammation. When senescent cells begin to accumulate and the immune system stops responding to them, these secretions can lead to age-related diseases, including osteoarthritis and atherosclerosis.

NAD+ metabolism can help remove senescent cells and alleviate chronic diseases related to aging. 

A circadian cycle is an internal regulatory process that is influenced by irregular eating patterns, sleep/wake time, light exposure, and age. NAD+ can improve sleep quality by modulating SIRT1, which regulates the expression of our circadian clock genes. 

How does NMN improve sleep quality?

The susceptibility of our circadian rhythm to external factors is often tangible: it can be easily influenced by our sleep/wake patterns, diet, exposure to light, and age.

However, the impact of disruptions to our circadian rhythm is not always immediately felt. For example, many studies show that sleeping with the lights on can disrupt our circadian rhythm and lead to obesity, myopia, and even growth disorders. However, in the short term, sleeping with the lights on may only result in a sense of poor sleep quality.

There are three pathways that help regulate our circadian cycle:

  • Positive feedback loop: Activation of circadian transcription by the heterodimeric factor CLOCK-BMAL1.
  • Negative feedback loop: Inhibition of circadian transcription by Period (PER) and Cryptochrome (CRY) proteins towards CLOCK-BMAL1.
  • Complex, interconnected processes: The activation and inhibition of the BMAL1 gene.

The SIRT1 enzyme connects the NAD+ pathway to the circadian transcription loops, forming the NAD+ – SIRT1 – CLOCK:BMAL1 – NAMPT – NAD+ pathway. Through this pathway, NAD+ levels regulate our circadian rhythm. Thus, consuming the right amount of the NAD+ precursor NMN can help restore our circadian rhythms.

Stress is prevalent in today’s society and often leads to suboptimal health, causing fatigue and a lack of energy.

NAD+ plays a crucial role in increasing ATP levels by maintaining mitochondrial fitness, thus boosting our energy.

What is the Mitochondria?

Mitochondria generate 95% of the chemical energy required to power the cell’s biochemical reactions. This chemical energy, produced in the form of adenosine triphosphate (ATP). It also plays a central role in cell growth and apoptosis, earning mitochondria the nickname “powerhouse” of cells.

Dysfunctions in mitochondria can result in decreased cell energy levels and disruptions to cell signaling, contributing to various health issues and the aging process.

Research indicates that 53% of entrepreneurs work more than 12 hours per day, leading to exhaustion and fatigue.

One of the causes of mitochondrial dysfunction is the loss of NAD+, a central enzyme in ATP production during cellular respiration, which provides energy for numerous reactions throughout the body.

In 2012, Shin-ichiro Imai, MD, PhD, a professor of developmental biology and medicine at Washington University School of Medicine, discussed the close correlation between cellular NAD+ levels and mitochondrial functions in his landmark paper “The Dynamic Regulation of NAD Metabolism in Mitochondria.”

As the immediate precursor of NAD+, NMN has been validated by numerous studies to rapidly increase NAD+ levels in our bodies, thus improving mitochondrial functions.

In 2020, a research team led by the University of Minnesota demonstrated that NMN treatment significantly increased cellular respiration and ATP production. Researchers found that NMN improved mitochondrial functions in RPE cells, with the most significant improvement observed at 24 hours, primarily measured by ATP production.

Studies on NMN/NAD+

In 2011, a research team at the Washington University School of Medicine, led by Shin-ichiro Imai, MD, PhD, found that NMN supplementation might be effective in Type 2 diabetes (T2D) patients.

In 2013, research led by David A. Sinclair, A.O., PhD, a professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, showed that declines in mitochondrial functions induced by a decrease in nuclear NAD+ can be reversible.

Regulatory Status of NMN

NMN is approved in Japan as a raw material.

NMN is approved by the FDA as an investigational new drug.

By combining an advanced drug delivery system with the highest-grade, 99.9% β-NMN concentrate, an ultra-premium, next-generation NAD+ supplement is created.

Suggested Use

1 to 4 tablets daily. As a rough guide, take 1 tablet per every 25 years of age.

For the best result, consume in the morning, with or without meals. Beginners should start with a lower dose and adjust gradually.

Always consult your healthcare professional prior to use. Do not use if you are pregnant or nursing. Not suitable for children under the age of 18.

NMN FAQs

1.   What is NMN?

NMN (Nicotinamide Mononucleotide) is a naturally occurring compound derived from vitamin B3. It serves as a direct precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme essential for cellular energy production, DNA repair, and overall metabolic health. NMN is crucial for maintaining NAD+ levels, which decline with age.

2.   What does NMN do?

NMN boosts NAD+ levels, activating key enzymes like sirtuins that regulate DNA repair, cellular health, and metabolic efficiency. It plays a role in maintaining mitochondrial function, protecting against oxidative stress, and slowing age-related decline by supporting efficient cellular processes.

▪️ Promotes Vascular Health and Blood Flow 
▪️ Improves Muscle Endurance and Strength 
▪️ May Help Protect Against Heart Disease 
▪️ Lowers Risk of Obesity 
▪️ Increases Mitochondrial Function 
▪️ Enhances DNA Repair 
▪️ Promotes Vascular Health and Blood Flow

3.   How does NMN work?

NMN is absorbed into cells and converted into NAD+, which fuels numerous biological processes including ATP production, DNA repair, and sirtuin activation. These processes are critical for energy metabolism and regulating cellular health, especially in aging cells where NAD+ levels drop significantly.

▪️ Responsible for the production of more than 95% of the cellular energy 
▪️ Signal transmission 
▪️ May Help Protect Against Heart Disease 
▪️ Anti-aging; Longevity 
▪️ DNA repair

4.   What is NMN made of?

​NMN is a simple molecule made from niacin (vitamin B3) that naturally occurs in the body. Our NMN15000 product is composed of 100% pure, pharmaceutical-grade NMN without any fillers or impurities, ensuring maximum effectiveness in boosting NAD+

▪️ Ribose – simple sugar and carb that forms NRA 
▪️ Nicotinamide – Form of Vitamin B3 
▪️ Niacin – essential human nutrient and form of Vitamin B3

5.   Is NMN safe?

Yes, NMN is safe and well-tolerated. It is a naturally occurring compound in the body, and research has shown it to be effective in boosting NAD+ levels without any significant adverse effects. Clinical trials continue to support its safety for long-term use. Researchers have been doing clinical trials to investigate the safety and efficacy of the molecule in humans for years. These studies are producing amazing results of the positive effects of NMN and its abilities in improving health. Of course, the goal is to develop treatments that slow ageing and reduce age-related diseases.

▪️ NMN is not a drug! 
▪️ NMN is an organic molecule in DNA that is naturally produced by the body. 
▪️ It is safe for consumption 
▪️ Our NMN is manufactured in NSF Certified facilities

6.   Is NMN the same as taking vitamins and minerals?

Taking NMN is different from taking vitamins and minerals, as they serve distinct roles in cellular processes. NMN acts as a precursor to NAD+, a molecule crucial for cellular energy production, DNA repair, and overall metabolic function. In contrast, vitamins and minerals are essential micronutrients that support a wide range of biological functions, including enzyme activity, immune support, and bone health. The absorption pathways also differ—NMN is absorbed and converted into NAD+ within cells, while vitamins and minerals follow different mechanisms for uptake and utilization. NMN specifically targets the enhancement of NAD+ levels, which directly influences mitochondrial function and cellular longevity, unlike general micronutrients.

7.   How is NMN going to help me as an athlete?

There are many benefits of taking NMN as an athlete. Reflexiv+ NMN15000 repairs DNA that has been damaged due to injury, strenuous exercise, illness, etc. and is the key to longevity. It has been shown to help athletes recover from injury quicker and has helped athletes sustain energy through single competitions as well as the long season. A younger, healthier body leads to a longer career! Learn much morehere

8.   Why not just take NR or NAD?

While both NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are precursors to NAD+ (nicotinamide adenine dinucleotide), NMN is thought to have a more direct pathway for conversion into NAD+ within cells. Some studies suggest that NMN may be more effective in boosting NAD+ levels and supporting cellular functions. Additionally, taking NR or NAD+ directly is less effective because it cannot easily cross cell membranes, making NMN a more viable option for increasing NAD+ levels. Each compound has its own benefits, but NMN may offer a more efficient route for enhancing NAD+ production.

Reflexiv+ NMN15000 is 99.9% starting active material pure and is able to directly transform into NAD+. After an athlete takes Reflexiv+ NMN, it is absorbed into the blood stream within 10 minutes and converted to NAD+ within 30 minutes!

9.   Why are we just hearing about NMN?

NMN was discovered in the 1960s, but widespread research into its benefits only began in recent years, particularly around its anti-aging and metabolic properties. As research continues to emerge, public awareness is growing. NMN remains relatively unknown in the U.S. due to its niche positioning within the broader supplement market and its association with specialized areas of metabolic and anti-aging research. While NMN plays a crucial role as a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme essential for cellular energy metabolism and DNA repair, the scientific community's focus on NMN has only recently gained momentum. Limited public awareness stems from the slow translation of promising research into mainstream health discourse and the lack of widespread commercial investment or FDA-approved claims.

10.   Is NMN banned in the U.S.?

No, NMN is legal and available as a dietary supplement in the U.S. The FDA has raised questions about its classification due to drug-related studies, but NMN remains on the market and is considered safe for consumption

11.   Are all NMN products the same?

No!! Not all NMN products are the same! Many NMN products contain impurities or low concentrations of NMN. Our NMN15000 is the only pharmaceutical-grade NMN, processed to ensure 100% purity without contaminants, making it far more effective than most products on the market.

12.   Is Reflexiv+ NMN made in the U.S.A?

​The answer is YES! Reflexiv+ NMN is manufactured here in the U.S. Our products are held to the highest standards of production. We only produce pharma-grade products. This means that it is the highest quality NMN on the market.

13.   What are 'related compounds'?

Because immediate release NMN capsules or powder products do not go through complex manufacturing processes like ours do, those products will not show much of “related compounds” if tested. Ours will. Related compounds are by-products that can form during NMN production. While they aren’t harmful in small amounts, they can reduce the overall effectiveness of the supplement if not properly removed during processing.

14.   Are the terms 'related compounds' and 'Impurities' the same?

No. Though the terms “related compounds” and “Impurities” have been used interchangeably, they are not the same. Related compounds are the compounds that are related to the intended active component, while impurities can include related compounds as well as other contaminants. Related compounds are natural by-products of manufacturing, whereas impurities are harmful substances like heavy metals or toxins. NMN15000 is free of both, ensuring the purest product possible.

15.   Is it more effective to take NAD IV drips?

Taking pure NMN supplements orally is more effective than NAD IV drips because NMN is a direct precursor to NAD+, allowing the body to efficiently convert it into NAD+ at the cellular level. Oral NMN is rapidly absorbed and bypasses the need for invasive procedures, making it more practical and consistent for long-term use. In contrast, NAD IV drips deliver NAD+ directly but are less efficient since NAD+ molecules are too large to easily cross cell membranes, limiting their overall effectiveness. Additionally, NMN supplements offer better bioavailability and convenience.

16.   How Much NMN should I take?

Taking human studies of efficacy and safety into consideration and calculating optimal NMN doses, the recommended dose that adults between 30 and 60 years old is to take 500 mg per day. People over age 65 can safely take 750 mg per day to maximize NMN’s benefits. However, tests in athletes and fitness-minded individuals of all ages have recently shown that taking 1000mg per day is optimal.

17.   Can NMN improve cognitive function?

Yes, research shows that NMN can enhance brain function by supporting mitochondrial health and protecting neurons from damage. This helps improve focus, memory, and overall cognitive performance.

18.  Can NMN help with weight management?

NMN enhances metabolic efficiency by supporting fat oxidation, helping the body burn fat more effectively. This can lead to better weight management and improved energy balance during physical activity.

 

Image

Reviews
5.0

Based on 5 ratings

Jerry Baldwin

Verified Buyer

Wow!!!
Wow!!! the mental clarity l got from this wasamazing!l don't know if it was from theenergy boost or what. But this is a must buy!

David

Verified Buyer

very good
I tried it for 3 days and it significantly increased my energy

michael

Verified Buyer

A good product
I feel more energy by taking this product. I used to drink a lot of energy drink like Red Bull per day at work. I no longer need those drinks now. Another good thing may relates to this product is my friends said I look younger. Initially I purchased this product for my mum, she said she feel good with the combination I recommended, I can see less age pigments on her face. And she said she sleeps very well now. I will keep purchasing